Structural and Systemic Neurobiology

(AG Lidia Bakota)

Hrynchak MV, Rierola M, Golovyashkina N, Penazzi L, Pump WC, David B, Sündermann F, Brandt, and Bakota L (2020) Chronic Presence of Oligomeric Aβ Differentially Modulates Spine Parameters in the Hippocampus and Cortex of Mice With Low APP Transgene Expression. Front. Synaptic Neurosci. 12:16

Brandt R, Trushina NI, and Bakota L (2020) Much more than a cytoskeletal protein: Physiological and pathological functions of the non-microtubule binding region of tau. Front. Neurol. 11:590059

Ortiz-Sanz C, Valero J, Bakota L, Brandt R, Zugaza JL, Matute C, and Alberdi E (2020) Early effects of amyloid beta oligomers on dendritic spine dynamics and arborization in hippocampal neurons. Front. Synaptic Neurosci. 12:2

Trushina NI, Bakota L, Mulkidjanian AY, and Brandt R (2019) The evolution of tau phosphorylation and interactions. Front. Aging Neurosci. 11:256

Schob C, Morellini F, Ohana O, Bakota L, Hrynchak MV, Brandt R, Brockmann MD, Cichon N, Hartung H, Hanganu-Opatz IL, Kraus V, Scharf S, Herrmans-Borgmeyer I, Schweizer M, Kuhl D, Wöhr M, Vörckel KJ, Calzada-Wack J, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, Garner CC, Kreienkamp HJ, Kindler S (2019) Cognitive impairment and autistic-like behaviour in SAPAP4-deficient mice. Transl. Psychiatry 9:7

Gauthier-Kemper A*, Suárez Alonso M*, Sündermann F, Niewidok B, Fernandez MP, Bakota L, Heinisch JJ, Brandt R (2018) Annexins A2 and A6 interact with the extreme N-terminus of tau and thereby contribute to tau’s axonal localization (*joint first authors). J. Biol. Chem. 293:8065-8076

Brandt R, and Bakota L (2017) Microtubule dynamics and the neurodegenerative triad of Alzheimer's disease: The hidden connection. J. Neurochem. 143:409-417

Bakota L, Ussif A, Jeserich G, and Brandt R (2017) Systemic and network functions of the microtubule-associated protein tau: Implications for tau-based therapies. Mol. Cell. Neuroscience 84:132-141

Penazzi L, Lorengel J, Sündermann F, Golovyashkina N, Marre S, Mathis CMB, Lewejohann L, Brandt R, and Bakota L (2017) DMSO modulates CNS function in a preclinical Alzheimer's disease model. Neuropharmacology 113:434-444

Bakota L, and Brandt R (2016) Tau Biology and Tau-Directed Therapies for Alzheimer's Disease. Drugs 76:301-313

Golovyashkina N, Sündermann F, Brandt R, and Bakota L (2014) Reconstruction and morphometric analysis of hippocampal neurons from mice expressing fluorescent proteins. NeuroMethods 87:251-262

Bakota L, Brandt R, and Heinisch JJ (2012) Triple mammalian/yeast/bacterial shuttle vectors for single and combined Lentivirus- and Sindbis virus-mediated infections of neurons. Mol. Genet. Genomics 287:313-324

Sündermann F, Golovyashkina N, Tackenberg C, Brandt R, and Bakota L (2012) High-resolution imaging and evaluation of spines in organotypic hippocampal slice cultures. Methods Mol. Biol. 846:277-293

Bakota L, and Brandt R (2009) Live cell imaging in the study of neurodegeneration. Int. Rev. Cell Mol. Biol. 276:49-103

Bakota L, Szikra J, Toth G, and Gulya K (1998) Slide-binding characterization and autoradiographic localization of delta opioid receptors in rat and mouse brains with the tetrapeptide antagonist (3H)TIPP. Life Sci. 63:1377-1385

Bakota L, and Brandt R (eds.) Confocal and multiphoton laser-scanning microscopy of neuronal tissue: Applications and quantitative image analysis. New York: Humana Press, 2014.

Rierola, Marina (2022) Distinct modulation of neuronal domains by Abeta, tau, and α-synuclein affects dendritic connectivity in hippocampal pyramidal neurons. Fachbereich Biologie/Chemie, Universität Osnabrück.
Hrynchak, Mariya (2021) Functional synergy of Abeta oligomers and human tau protein in mice and ex vivo cultures. Fachbereich Biologie/Chemie, Universität Osnabrück.
Ussif, Abdala Mumuni (2019) Effects of MAPtau knockout on electrophysiological, biochemical and dendritic morphometric parameters. Fachbereich Biologie/Chemie, Universität Osnabrück.
Penazzi, Lorène (2016) Pharmacological intervention to reverse structural and functional changes in neurons chronically exposed to moderate Aß levels. Fachbereich Biologie/Chemie, Universität Osnabrück.