NEW PHD POSITION (application period is closed):
The Department of Neurobiology is hiring a research assistant (m/f/d) to start on March 16, 2025 (or later). The position is limited to three years with the possibility of an extension.
Deadline for applications: January 17, 2025.

PUBLISHED AHEAD OF PRINT (January 13, 2025):
Lidia Bakota and Roland Brandt (2025) Towards mechanism-based tau-targeted therapies. Neural Regen Res DOI: 10.4103/NRR.NRR-D-24-01240

RECENT PREPRINT:
Davide di Lorenzo, Nicolo Bisi, Raffaella Bucci, Inga Ennen, Leonardo Lo Presti, Veronica Dodero, Roland Brandt, Sandrine Ongeri, Maria-Luisa Gelmi, Nicolo Tonali: Application of modular isoxazoline-β2,2-amino acid-based peptidomimetic foldamers as a chemical model system for studying the tau misfolding mechanism. (bioRxiv)

RECENT PREPRINT:
Davide Di Lorenzo, Nicolo Bisi, Julia Kaffy, Lisa Marie Ramirez, Markus Zweckstetter, Olivier Lequin, Irene Garfagnini, Jinghui Luo, Yvonne Hannappe, Inga Ennen, Veronica Dodero, Norbert Sewald, Maria Luisa Gelmi, Nicolo Tonali, Roland Brandt* and Sandrine Ongeri*: Synthetic chaperone based on Hsp90-Tau interaction inhibits pathological Tau aggregation and rescues physiological Tau-Microtubule interaction. (*joined corresponding authors) (bioRxiv)

RECENT PREPRINT:
Christian Conze, Nataliya I. Trushina, Nanci Monteiro-Abreu, Daniel Villar Romero, Eike Wienbeuker, Anna-Sophie Schwarze, Michael Holtmannspötter, Lidia Bakota, Roland Brandt: Redox signaling by hydrogen peroxide modulates axonal microtubule organization and induces a specific phosphorylation signature of microtubule proteins distinct from distress. (bioRxiv)
(Audio summary on ScienceCast)

RECENT PREPRINT:
Marina Rierola, Nataliya I. Trushina, Nanci Monteiro-Abreu, Christian Conze, Michael Holtmannspötter, Rainer Kurre, Max Holzer, Thomas Arendt, Jürgen J. Heinisch, Roland Brandt and Lidia Bakota: Tau and α-synuclein shape microtubule organization and microtubule-dependent transport in neuronal dendrites. (bioRxiv)

SCIENTIFIC PRESENTATIONS OF MEMBERS OF THE DEPARTMENT:
- February 17-19,2025: International Conference on Central Nervous System Disorders: From Mechanisms to Medicine (ICCNS-2M-2025), National Institute of Pharmaceutical Education and Research (NIPER), Gandhinagar, India (R. Brandt: plenary speaker)
  
PUBLIC OUTREACH:
The Department of Neurobiology participates in the "Forschungsbörse" of the Ministry of Science and Education (Bundesministerium für Bildung und Forschung, BMBF).
University-school partnership "Neurobiologie macht Schule": School visits at the Irena-Sendler-Gesamtschule in Ahaus (6.02.2025), and from the Fürstenberg-Gymnaisum in Recke (20.03.2025).
"Webinar Volkshochschulen Deutschland" (in German): "Stand des Wissens: Was steckt hinter der Alzheimer-Krankheit" (23.10.25)"



In 2002, a new Department of Neurobiology was installed on a lab space of about 200 square meters and a functional space of additional 100 square meters in the Institute of Biology at the University of Osnabrück. The Department belongs to the School of Biology/Chemistry and is associated with the Institute of Cognitive Science. The research of the Department focusses on the mechanisms of neural development and degeneration on the molecular, cellular and systemic level (Research Mission). Techniques include S1 and S2 cell and organotypic culture (including gene transfer with Sindbis and Lentivirus), laser scanning microscopy and quantitative image analysis, electrophysiology (extracellular recordings using microelectrode arrays), and breeding, genotyping and characterization of transgenic mouse lines. Teaching involves participation in the Bachelor program "Biologie", the Bachelor program "Cognitive Sciences", the Master program "Biologie/Biology - from Molecules to Organisms" and the Master program "Nanosciences - Materials, Molecules and Cells". The Department consists of three research groups (AG Bakota, AG Brandt and AG Jeserich (retired)). Every two years, members of the Department organize the Westerberger Herbsttagung. The Department is part of the Center of Cellular Nanoanalytics Osnabrück (CellNanOs).  



Seminar room Neurobiology (room 36-334)

Date	Speaker and Title
Tuesday, January 28, 11 am	"Introduction to applied statistics" (L. Borba)
Tuesday, February 25, 11 am	Yearly Safety Instructions: General lab safety, Biological safety (W. Hamann, R. Brandt)
Coming soon	FELASA Meeting report part 1: "Creating and maintaining genetically altered animals" (L. Bakota)
Coming soon	FELASA Meeting report part 2: "Experimental design" (L. Bakota)

Attendance is mandatory for bachelor, master, doctoral and postdoctoral members of the Department and open to everybody.
Seminar language is English